By Sara E. Rosenbaum
Up to date with new chapters and themes, this publication offers a entire description of all crucial themes in modern pharmacokinetics and pharmacodynamics. It additionally good points interactive laptop simulations for college students to test and discover PK/PD types in action.
• Presents the necessities of pharmacokinetics and pharmacodynamics in a transparent and innovative manner
• Helps scholars greater have fun with vital ideas and achieve a better figuring out of the mechanism of motion of substances via reinforcing functional functions in either the e-book and the pc modules
• Features interactive laptop simulations, to be had on-line via a better half web site at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html• Adds new chapters on physiologically dependent pharmacokinetic versions, predicting drug-drug interactions, and pharmacogenetics whereas additionally strengthening unique chapters to raised organize scholars for extra complicated applications
• Reviews of the first version: “This is a perfect textbook for these beginning out … and in addition to be used as a reference publication …." (International Society for the research of Xenobiotics) and “I may suggest Rosenbaum’s ebook for pharmacology scholars since it is written from a point of view of drug motion . . . total, it is a well-written advent to PK/PD …. “ (British Toxicology Society publication)
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Additional resources for Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations
4. 5. 6. Distinguish passive diffusion and transporter-mediated passage Distinguish transcellular and paracellular transport Identify membrane and drug factors that control passive diffusion Distinguish uptake and efflux transporters Become familiar with members of the SLC and ABC superfamilies Understand how transporters affect pharmacokinetics and pharmacodynamics Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations, Second Edition. Edited by Sara E. Rosenbaum.
1 Plasma Concentration of Drugs As stated above, pharmacokinetics is concerned with the body’s exposure to a drug and how drug concentrations change over time. For the most part, drug concentrations in the plasma are the focus in pharmacokinetics. The rationale for this is twofold. First, blood is one of the few body fluids that can be obtained and analyzed repeatedly for drug concentrations at specified times after the administration of a dose. The concentration of drug in whole blood is not commonly used in pharmacokinetics because blood is a complex physical system that consists of red blood cells, white blood cells, and platelets suspended in plasma water.
During each process in ADME, a drug may have to pass across several membranes. For example, orally administered drugs must pass through the gastrointestinal wall into the interstitial fluid and then through the capillary membrane to enter the blood. From there, they may have to pass several other membranes to access their site of action and to be removed from the body. Drugs penetrate these membranes by either passive diffusion or by a transport-mediated process. 3 PASSIVE DIFFUSION Passive diffusion is the most common way for drugs to pass through biological membranes.