By Fausto Rodriguez, Cheng-Ying Ho
This publication is a wealthy resource of data on biomarkers appropriate to the pathology of neoplastic issues of the mind. Thorough descriptions are supplied of the strategies at present to be had for scientific and experimental review of biomarkers in mind neoplasms, together with in situ hybridization, array-based tools, methylation profiling, next-generation sequencing, and functional gene panels. Incorporation of a number of biomarkers within the improvement of molecular subgroups with biologic and healing relevance can also be mentioned. a piece on biobanking covers the both very important subject of optimum protection of tissue and comprises attention of moral concerns raised via tissue got in scientific settings. The ultimate part discusses the key different types of neoplastic problems regarding the anxious method, with emphasis on diagnostic, prognostic, and predictive biomarkers utilized in the pathologic evaluate of alternative forms of mind tumor.
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Extra resources for Biomarkers in Neoplastic Neuropathology
Currently, many biobanks adopt the “open consent” mechanism – a single broad consent for all future use of biomaterial and data . While the requirement of a “purpose-limited consent” for specific research activity remains debatable, many will agree that the consent needs to comply with individual institutional regulations and government laws. Snap-Frozen Tissue Formalin-fixed, paraffin-embedded (FFPE) tissue stored in diagnostic pathology archives represents the major source of solid tissue samples in most biobanks.
Coupled with microarray-based analyses, MIRA is a powerful tool to provide high-resolution genome-wide methylation profiling. Bisulfite Conversion-Based Assays The gold standard for DNA methylation analysis of individual genes is bisulfite treatment of DNA followed by microarray analysis or sequencing . Bisulfite treatment of DNA converts unmethylated cytosine residues to uracil but leaves 5-methylcytosine residues unaltered. Cytosines converted to uracil will be recognized as thymine, whereas bisulfite-resistant 5-methylcytosines remain as cytosines in subsequent PCR amplification and sequencing .
P 1–16 44 2 Special Techniques 79. Nakamura K et al (2011) Sequence-specific error profile of Illumina sequencers. Nucleic Acids Res 39(13), e90 80. Loman NJ et al (2012) Performance comparison of benchtop high-throughput sequencing platforms. Nat Biotechnol 30(5):434–439 81. Alexandrov LB et al (2013) Signatures of mutational processes in human cancer. Nature 500(7463):415–421 82. Kandoth C et al (2013) Mutational landscape and significance across 12 major cancer types. Nature 502(7471):333–339 83.